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dc.contributor.authorDuarte, N-
dc.contributor.authorJárdánházy, A-
dc.contributor.authorRamalhete, Cátia-
dc.contributor.authorMolnar, J-
dc.contributor.authorFerreira, MJU-
dc.identifier.citationInternational Congress and 55th Annual Meeting of the Society for Medicinal Plant Researchpt_PT
dc.description.abstractThe aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated.-
dc.titleSynergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cellspt_PT
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