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Title: Computational Challenges in Tissue Engineering for The Spine
Authors: Castro, A. P. G.
Keywords: Spine
Intervertebral disc
Tissue engineering
Finite element modelling
Issue Date: Feb-2021
Publisher: Bioengineering
Citation: Castro, A.P.G. (2021). Computational Challenges in Tissue Engineering for The Spine. Bioengineering. Disponível em https://doi.
Abstract: Abstract: This paper deals with a brief review of the recent developments in computational modelling applied to innovative treatments of spine diseases. Additionally, it provides a perspective on the research directions expected for the forthcoming years. The spine is composed of distinct and complex tissues that require specific modelling approaches. With the advent of additive manufacturing and increasing computational power, patient-specific treatments have moved from being a research trend to a reality in clinical practice, but there are many issues to be addressed before such approaches become universal. Here, it is identified that the major setback resides in validation of these computational techniques prior to approval by regulatory agencies. Nevertheless, there are very promising indicators in terms of optimised scaffold modelling for both disc arthroplasty and vertebroplasty, powered by a decisive contribution from imaging methods.
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