http://hdl.handle.net/10884/1280 2026-04-27T20:34:43Z http://hdl.handle.net/10884/1507 Title: Mateiais Compositos Authors: Freitas, Manuel Abstract: lknkjh Description: lihgjb 2020-04-05T00:00:00Z http://hdl.handle.net/10884/1496 Title: On the Tortuosity of TPMS Sca olds for Tissue Engineering Authors: Guerreiro, R.; Pires, T.; Guedes, J. M.; Fernandes, P. R.; Castro, A. P. G. Abstract: Abstract: Recently, bone tissue engineering (TE) has seen new developments, with triply periodic minimal surfaces (TPMSs) being used to develop new porosity-controlled sca olds to interface new tissue growth. The process of choosing the best geometry to a specific application still lacks research, so the goal for this work is to propose a new method of sca old selection, based on assessing the tortuosity inside these symmetric TPMS-based structures. Additionally, computer fluid dynamic (CFD) simulations were conducted to validate this method. The comparison between tortuosity and CFD outputs suggests that an analysis of the tortuosity could be used as an early indicator of the sca old’s viability for specific applications, favouring sca olds with more intricate and curvature-dependent streamlines. 2020-04-01T00:00:00Z http://hdl.handle.net/10884/1495 Title: Finite element modelling of the developing infant femur using paired CT and MRI scans Authors: Castro, A. P. G.; Altai, Z.; Offiah, A. C.; Shelmerdine, S. C.; Arthurs, O. J.; Lacroix, D.; Li, X. Abstract: Bone finite element (FE) studies based on infant post-mortem computed tomography (CT) examinations are being developed to provide quantitative information to assist the differentiation between accidental and inflicted injury, and unsuspected underlying disease. As the growing skeleton contains non-ossified cartilaginous regions at the epiphyses, which are not well characterised on CT examinations, it is difficult to evaluate the mechanical behaviour of the developing whole bone. This study made use of paired paediatric post mortem femoral CT and magnetic resonance imaging (MRI) examinations at two different stages of development (4 and 7 months) to provide anatomical and constitutive information for both hard and soft tissues. The work aimed to evaluate the effect of epiphyseal ossification on the propensity to shaft fractures in infants. The outcomes suggest that the failure load of the femoral diaphysis in the models incorporating the non-ossified epiphysis is within the range of bone-only FE models. There may however be an effect on the metaphysis. Confirmation of these findings is required in a larger cohort of children. 2019-01-01T00:00:00Z http://hdl.handle.net/10884/1494 Title: Computational Challenges in Tissue Engineering for The Spine Authors: Castro, A. P. G. Abstract: Abstract: This paper deals with a brief review of the recent developments in computational modelling applied to innovative treatments of spine diseases. Additionally, it provides a perspective on the research directions expected for the forthcoming years. The spine is composed of distinct and complex tissues that require specific modelling approaches. With the advent of additive manufacturing and increasing computational power, patient-specific treatments have moved from being a research trend to a reality in clinical practice, but there are many issues to be addressed before such approaches become universal. Here, it is identified that the major setback resides in validation of these computational techniques prior to approval by regulatory agencies. Nevertheless, there are very promising indicators in terms of optimised scaffold modelling for both disc arthroplasty and vertebroplasty, powered by a decisive contribution from imaging methods. 2021-02-01T00:00:00Z