DSpace Collection:
http://hdl.handle.net/10884/1280
2024-03-28T23:15:01ZMateiais Compositos
http://hdl.handle.net/10884/1507
Title: Mateiais Compositos
Authors: Freitas, Manuel
Abstract: lknkjh
Description: lihgjb2020-04-05T00:00:00ZOn the Tortuosity of TPMS Sca olds for Tissue Engineering
http://hdl.handle.net/10884/1496
Title: On the Tortuosity of TPMS Sca olds for Tissue Engineering
Authors: Guerreiro, R.; Pires, T.; Guedes, J. M.; Fernandes, P. R.; Castro, A. P. G.
Abstract: Abstract: Recently, bone tissue engineering (TE) has seen new developments, with triply periodic
minimal surfaces (TPMSs) being used to develop new porosity-controlled sca olds to interface
new tissue growth. The process of choosing the best geometry to a specific application still lacks
research, so the goal for this work is to propose a new method of sca old selection, based on
assessing the tortuosity inside these symmetric TPMS-based structures. Additionally, computer
fluid dynamic (CFD) simulations were conducted to validate this method. The comparison between
tortuosity and CFD outputs suggests that an analysis of the tortuosity could be used as an early
indicator of the sca old’s viability for specific applications, favouring sca olds with more intricate
and curvature-dependent streamlines.2020-04-01T00:00:00ZFinite element modelling of the developing infant femur using paired CT and MRI scans
http://hdl.handle.net/10884/1495
Title: Finite element modelling of the developing infant femur using paired CT and MRI scans
Authors: Castro, A. P. G.; Altai, Z.; Offiah, A. C.; Shelmerdine, S. C.; Arthurs, O. J.; Lacroix, D.; Li, X.
Abstract: Bone finite element (FE) studies based on infant post-mortem computed tomography (CT)
examinations are being developed to provide quantitative information to assist the differentiation
between accidental and inflicted injury, and unsuspected underlying disease. As the
growing skeleton contains non-ossified cartilaginous regions at the epiphyses, which are
not well characterised on CT examinations, it is difficult to evaluate the mechanical behaviour
of the developing whole bone. This study made use of paired paediatric post mortem
femoral CT and magnetic resonance imaging (MRI) examinations at two different stages of
development (4 and 7 months) to provide anatomical and constitutive information for both
hard and soft tissues. The work aimed to evaluate the effect of epiphyseal ossification on
the propensity to shaft fractures in infants. The outcomes suggest that the failure load of the
femoral diaphysis in the models incorporating the non-ossified epiphysis is within the range
of bone-only FE models. There may however be an effect on the metaphysis. Confirmation
of these findings is required in a larger cohort of children.2019-01-01T00:00:00ZComputational Challenges in Tissue Engineering for The Spine
http://hdl.handle.net/10884/1494
Title: Computational Challenges in Tissue Engineering for The Spine
Authors: Castro, A. P. G.
Abstract: Abstract: This paper deals with a brief review of the recent developments in computational modelling
applied to innovative treatments of spine diseases. Additionally, it provides a perspective on
the research directions expected for the forthcoming years. The spine is composed of distinct and
complex tissues that require specific modelling approaches. With the advent of additive manufacturing
and increasing computational power, patient-specific treatments have moved from being a
research trend to a reality in clinical practice, but there are many issues to be addressed before such
approaches become universal. Here, it is identified that the major setback resides in validation of
these computational techniques prior to approval by regulatory agencies. Nevertheless, there are
very promising indicators in terms of optimised scaffold modelling for both disc arthroplasty and
vertebroplasty, powered by a decisive contribution from imaging methods.2021-02-01T00:00:00Z